a, matthews bg, et al. inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. blood 2014;12

Answers

Answer 1

Both in people and animals, acute myeloid leukemia reduces the number of osteoblasts.

A pharmaceutical approach to osteoblast restoration in leukemic mice decreases tumor burden across the board and lengthens survival.

According to theory, the bone marrow niche serves as a permissive microenvironment necessary for the genesis or development of hematopoietic malignancies. We proposed that leukemic blasts are influenced by osteoblasts, niche elements vital to hematopoietic stem cell (HSC) activity.In mice models of acute leukemia, genetic osteoblast depletion increased the number of circulating blasts and tumor engraftment in the marrow and spleen, which raised tumor burden and decreased survival. Hematopoietic lineage/progression may have been altered since myelopoiesis rose, was accompanied by a decline in B lymphopoiesis, and was impaired by erythropoiesis.Osteoblast loss was prevented in mice with acute myeloid or lymphoblastic leukemia treated with a pharmaceutical inhibitor of the manufacture of duodenal serotonin, a hormone that reduces the number of osteoblasts.

Therefore, osteoblasts and leukemia are related.

Learn more about Leukemia:

https://brainly.com/question/20884905

#SPJ4


Related Questions

a procedure that attempts to obstruce the blood flow to a maligant tumor would be in what root operation for icd 10 pcs

Answers

According to ICD- 10 PCS root operations that alter the diameter/route of a tubular body part will be used to obstruct the blood flow to a malignant tumor. This is called occlusion.

Occlusion involves completely closing an orifice or the lumen of a tubular body part. It can include intraluminal or extraluminal devices. Here, any division of the body part prior to the procedure is included. For example, Fallopian tube ligation, tying off hemorrhoids, LIGATION of the inferior vena cava.

Malignant tumors have cells that grow uncontrollably and spread locally and/or to distant sites. Malignant tumors are cancerous (ie, they invade other sites). They spread to distant sites via the bloodstream or the lymphatic system. This spread is called metastasis.

To know more about Malignant tumors here

brainly.com/question/12020868

#SPJ4

This type of endocytosis is the cellular process of engulfing liquid particles by the cell membrane.

Answers

The type of endocytosis is the cellular process of engulfing liquid particles by the cell membrane is called pinocytosis

Pinocytosis refers to how living cells consume liquid droplets. Pinocytosis is a type of endocytosis, which is the method by which cells envelop external substances and collect them in special membrane-bound vesicles inside the cell. Pinocytosis occurs when a droplet of the liquid becomes bound, or reabsorbed, on the cell membrane. It then invaginates (creates a pocket) and pinches off to create a vesicle in the cytoplasm instead of a single droplet of liquid traveling inactively through the cell membrane.

To learn more about pinocytosis: brainly.com/question/14776020

#SPJ4

The biomass pyramids for phytoplankton and trees in their respective environments are _______. a. both inverted b. the same c. opposite d. both normal please select the best answer from the choices provided a b c d

Answers

The biomass pyramids for phytoplankton and trees in their respective environments are opposite.

In the field of ecology, a biomass pyramid can be described as a pyramid that represents the biomass i.e the amount of living tissue at each trophic level in an ecosystem.

Usually, the biomass of producers is the greatest in an ecosystem and it decreases while going up at each trophic level. Producers such as trees are usually higher in number and have a larger life span. Hence, their biomass is greater than consumers.

However, the case is the opposite in the case of phytoplanktons. If phytoplanktons are the producers in an ecosystem, then the pyramid of biomass is inverted.

This is because phytoplanktons have a short life span and also are very tiny having little mass. As compared to phytoplanktons, the consumers of such an ecosystem have a greater mass and life span. Hence, the pyramid for trees and phytoplanktons is the opposite.

To learn more about biomass pyramids, click here:

https://brainly.com/question/14353680

#SPJ4

An older patient visits the doctor and learns that they have a disease known as atherosclerosis,
where there is a build-up of fat and cholesterol inside their blood vessels. An illustration of this
condition is shown in the image below.
Which of the following is a result of their condition?
A. increased blood volume
B. decreased blood volume
C. increased blood pressure
D. decreased blood pressure

Answers

C i think i could be wrong!

you can tell the age of a yeast cell by group of answer choices counting scars seeing whether it will grow on melibiose studying its flocculation total cell count

Answers

You can tell the age of a yeast cell by (a) counting scars.

Yeast is a unicellular eukaryotic organism. It belongs to the kingdom Fungi. It is primarily used in baking, cooking and in alcohol industries as well. There are various strains of yeast and the most widely used one is Saccharomyces cerevisiae, also called the baker's or the brewer's yeast.

Scars on the yeast are actually the bud scars formed due to budding. Budding is the process by which the yeast reproduces and gives rise to its offspring. Hence every time a daughter bud pinches off from the yeast cell, a scar is formed.

To know more about yeast, here

brainly.com/question/28213330

#SPJ4

What structures do all of these cells have in common?

Answers

Answer: All have a cytoplasam, plasma membrane, DNA, and ribosomes

IV - amount of water
DV - Rate of photosynthesis
What’s the hypothesis

Answers

Answer:

[tex]H_{0}[/tex]: The amount of water will have no effect on the rate of photosynthesis.

[tex]H_{1}[/tex]: A larger amount of water will increase the rate of photosynthesis.

[tex]H_{0}[/tex] means null hypothesis, a hypothesis where the independent variable, in this case, the amount of water, has no effect on the dependent variable.


Which of the following agricultural practices decreases biodiversity?
O Tiling soil
O Monoculture
O Synthetic fertilizers
O Flood irrigation

Answers

Monoculture I guess

Match the following vocabulary terms to their correct definitions.
Does NOT contain carbon.

Answers

Organic is carbon containing so inorganic is non carbon containing

Explain why it's advantageous to have several different organ systems instead of one large system to handle all of the human body's functions.

Answers

Answer:

Explanation:

Just as organs in an organ system work together to accomplish their task, so the different organ systems also cooperate to keep the body running. The respiratory system, and the circulatory system work closely together to deliver oxygen to cells and to get rid of carbon dioxide the cells produce.

Which policy design will BEST ensure that brine shrimp will continue to live in the Great Salt Lake?

Answers

The Marine Protection, Research, and San.ctuaries Act is the legal framework that will most effectively guarantee that brine shrimp will continue to exist in the Great Salt Lake.

Describe a policy:

This is referred to as a plan or set of rules that are established by people or organizations in order to accomplish long-term objectives.

By guaranteeing that there is no population from diverse sources, the Marine Protection, Research, and San/ctuaries Act was established to safeguard the marine environment.

The brine shri/mp, a representative of an organism that lives in the salt\ water environment, may migrate from the Great Salt Lake to more suitable locations as it becomes contaminated.

To learn more about Policy Visit

brainly.com/question/1064937

#SPJ1

calcium signaling in individual app/ps1 mouse dentate gyrus astrocytes increases ex vivo with aβ pathology and age without affecting astrocyte network activity

Answers

Astrocytes are a group  of cells with functional characteristics and distinctive morphological that vary within specific areas of the brain.

For healthy brain function, astrocytes are essential. those become reactive in the case of Alzheimer's disease, which impacts the signaling properties. while experimenting, there was the measurement for instinctive calcium transients ex vivo in hippocampal astrocytes in brain slices containing the dentate gyrus of  9-month-old  and 6-month-old APPswe/PSEN1dE9 mice. when they investigated the duration of calcium transients and frequency concerning amyloid-β (Aβ) pathology, the proximity of the astrocyte to Aβ plaques, and aging. there was no change in spontaneous calcium-transient properties of 6M APP/PS1 astrocytes compared to wild-type astrocytes, whereas there was hyperactivity in 9M APP/PS1 astrocytes compared to wild -type,  which were longer in duration, also there was an effect of aging too, there was an increase in calcium in the 9-month astrocytes than to the 6-month astrocytes, also there was an increase in the calcium waves in the 9-month astrocytes because of the increase network activity. The findings were that the change in calcium signaling in individual astrocytes of APP/PS1 mice is because of both pathology and aging but these don't have any impact on changes in the astrocyte network activity, which leads to helping to understand changes in neuronal physiology.

To know more about neuronal physiology refer to the link https://brainly.com/question/17060419?referrer=searchResults.

#SPJ4

An increase in the membrane permeability for a solute will result in an increase in the driving force for diffusion of that solute through the membrane. True or false?.

Answers

An increase in the membrane permeability for a solute will result in an increase in the driving force for diffusion of that solute through the membrane. This statement is TRUE.

Surface area and porosity/permeability are the two variables that are most relevant to diffusion via a membrane. Slower diffusion will result from a membrane with less permeability or less surface area, which will obstruct molecule motion. More permeable cells can withstand cold and freezing more easily, but they could also become dehydrated. Living cells are suspended in an aqueous solution, and as the cells move through the solution, ice crystals begin to form in the solution around them, increasing the concentration of solutes outside the cells.

Learn more about permeability

https://brainly.com/question/7670840

#SPJ4

prions are infectious particles that can cause normal proteins to assume a misfolded shape. when the proteins assume an abnormal three- dimensional shape, they:

Answers

Prions are infectious particles that can cause normal proteins to assume a misfolded shape and when the proteins assume an abnormal 3D shape, they lose their functions.

What is protein fold?

After synthesis, proteins are finally folded into specific 3D structures, which is fundamental to carrying out their functions in the cells.

In conclusion, prions are infectious particles that can cause normal proteins to assume a misfolded shape and when the proteins assume an abnormal 3D shape, they lose their functions.

Learn more about protein fold here:

https://brainly.com/question/3905959

#SPJ1

Question 2(Multiple Choice Worth 4 points)
(01.05 MC)
The Midwest United States is dominated by grasslands and food crops. Which abiotic factors of temperate grasslands create rich
soils for farmland?
Low precipitation and distinct seasons
O Distinct summers and winters; high rainfall.
O Mild winters, high precipitation, and lack of trees
1
High precipitation and little seasonal change

Answers

The abiotic factors of temperate grasslands that would create rich soils for farmland are distinct summers and winters; high rainfall. That is option B.

What are abiotic factors in an ecosystem?

Abiotic factors are those factors that are found in the environment of an ecosystem which are non living and cam influence the activities of organisms inhabiting that ecosystem.

Examples of abiotic factors that affect the temperate grassland include the following:

wind, soil, rocks,water, sun light, air, wind, temperature, lightning, rain, and climate change.

Soil fertility is enhanced in the presence of rainfall and distinct or controlled seasonal changes.

Therefore, the abiotic factors of temperate grasslands that would create rich

soils for farmland are distinct summers and winters; high rainfall.

Learn more about abiotic factors here:

https://brainly.com/question/23531525

#SPJ1

218k reber, a burki, n vizcaino reves, et al.: biomechanical evaluation of the stabilizing function of the atlantoaxial ligaments under shear loading: a canine cadaveric study. vet surg. 42:918-923 2013 24117887

Answers

ROM grew similarly and gradually during the test. The transsection of the alar ligaments resulted in the greatest rise.

To stabilise the atlantoaxial joint under shear pressure, the alar ligaments appear to be the most significant ligamentous structures.

What is Biomechanical evaluation ?

The evaluation of your body's full kinetic chain, which includes your legs, hips, and spine, is part of the biomechanical process. The angular relationships, range of motion, and dynamic interactions are all included.

An evaluation of the lower limbs' anatomy, alignment, strengths, and weaknesses is part of the biomechanical process. The foot, which carries our body weight as we walk every day, is a complicated structure made up of 28 separate bones, 214 ligaments, and 38 muscles.

Learn more about Biomechanical evaluation here:

https://brainly.com/question/20500161

#SPJ4

da luz, protásio l., et al. the effect of red wine on experimental atherosclerosis: lipid-independent protection. experimental and molecular pathology 65.3 (1999): 150-159.

Answers

To examine the impact of red wine on atherosclerosis, New Zealand rabbits were given a 1% cholesterol weight-reduction plan for 12 weeks and compared to animals that received the weight loss program plus either red wine or nonalcoholic wine merchandise (NAWP). Diet brought about a marked will increase in whole and LDL cholesterol, yet no tremendous modifications in HDL and triglyceride concentrations occurred. In the manage group, plaque vicinity used to be sixty-nine +/- 9% of the aortic surface, whilst in the wine and NAWP agencies, it was only 38 +/- 9 and forty-seven +/- 12%, respectively (P < 0.0001). The average intima/media thickness ratio was once 0.60 +/- 0.2 in manage animals, 0.14 +/- 0.09 in the wine group, and 0.39 +/- 0.19 in the NAWP team (P < 0.0001). No widespread variations have been referred to in LDL oxidizability among treatments. Thus, each red wine and NAWP can prevent plaque formation in hypercholesterolemic rabbits regardless of the extensive will increase in LDL. We speculate that the anti-platelet effect, blockade of expression of endothelial cellphone adhesion molecules, and/or NO stimulation with the aid of red wine flavonoids are possible explanations.

Wine is an alcoholic drink typically made from fermented grapes. Yeast consumes the sugar in the grapes and converts it to ethanol and carbon dioxide, releasing warmth in the process.

Learn more about Wine here:

https://brainly.com/question/23084323

#SPJ4

american society of hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism

Answers

Deep vein thrombosis (DVT), pulmonary embolism (PE), and other types of venous thromboembolism (VTE) affect 1 to 2 people per 1000 people yearly, or 300 000 to 600 000 cases in the United States.

Strong recommendations include using thrombolytic therapy for patients with PE and hemodynamic compromise, choosing an INR range of 2.0 to 3.0 for patients with VTE who use a vitamin K antagonist (VKA) for secondary prevention, and using indefinite anticoagulation for patients with recurrent unprovoked VTE. For uncomplicated DVT and PE at low risk for complications, conditional recommendations include the preference for home treatment over hospital-based treatment, and the preference for direct oral anticoagulants over VKA for primary treatment of VTE.

To know more about Deep vein thrombosis here

brainly.com/question/7023021

#SPJ4

Why does a prokaryotic cell have a cell wall

Answers

Answer:

Most prokaryotes have a cell wall outside the plasma membrane. The cell wall functions as a protective layer, and it is responsible for the organism’s shape. Some bacterial species have a capsule outside the cell wall.

Explanation:

Phycobiliproteins are complex proteins in cyanobacteria that absorb light energy. There are three kinds of phycobiliprotein molecules used to pass light to chlorophyll: phycoerythrin—responsible for capturing green light, phycocyanin—responsible for capturing orange-red light, and allophycocyanin—responsible for capturing red light.

Since light can only penetrate to certain depths in oceans (figure 1), phycobiliproteins capture the light available and pass it through various pathways of phycobiliproteins until the emitted light is red, which is absorbed by chlorophyll.



Explain the relationship between chlorophyll absorption and wavelength.
In addition to the pigments commonly associated with photosynthesis, a certain photosynthetic species contains two additional pigment types. Justify the claim that this species is better adapted to environmental changes than the cyanobacteria described above. Provide reasoning that explains this claim.

Answers

Answer:

since chlorophyll are only able to absorb the red, then the relationship is that the shorter the wavelength the better the chlorophyll will absorb the light for the bacteria. the second species will therefore be able to absorb more different wavelengths of light to turn it into the red light that can then be absorbed, in case the wavelengths of light that reach the bacteria in the ocean changed for some reason

knockout of the circadian clock protein per1 exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats

Answers

Knockout of the circadian clock protein per1 exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats resulting in worsening of the SS hypertensive phenotype (1).

A circadian clock factor BMAL1, significantly found in kidneys, is known to affect blood pressure. Moreover, a diet high in salt is associated with immune cell infiltration in the kidney and consequently increases blood pressure. The BMAL1 factor is also responsible for expressing various genes. Mice, when treated with BMAL1 showed aging phenotypes like muscle weakness, changed gait, decreased mobility, inactivity, etc.

PER1 is a circadian clock transcription factor and is regulated by aldosterone. Nice on PER1 knock-out develops reduced sodium excretion with day and night differences. This is done in response to a high-salt diet.

To know more about hypertension, refer to the following link:

https://brainly.com/question/26093747

#SPJ4

How many moles of iron will be made from 13.54 moles of carbon?

Answers

Answer:

0.01790670606142 that's your answer

describe the formation of platelets from pluripotent stem cells, including the influence of hormones.

Answers

The formation of platelets from pluripotent stem cells, including the influence of hormones.

Pluripotent stem cells form are the cells that can form all the cells of the body including ectoderm, mesoderm and endoderm but not the extra-embryonic structures like placenta.

Platelets are formed by a precursor cell called megakaryocyte which are present in the bone marrow. It is actually present in the kidney in the form of myeloid stem cells which forms the megakaryoblast which transforms into megakaryocytes.

Thousands of plateletes are formed by the megakarocytes. Thrombopoietin is the hormone which regulates plateletes formation.

to learn more about pluripotent stem cell here

https://brainly.com/question/14053639

#SPJ4

circle the bacterial structures that are located on the surface of a bacteria cell:  cell wall  pilus  nucleoid  capsule  flagella  ribosomes

Answers

The cell wall, capsule, pilus, and flagella are the bacterial structure that is located on the surface of a bacterial cell.

Cell wall: It is composed of a protein-sugar(polysaccharide) molecule which gives the cell its shape, and rigidity and protects it from the environment.

Capsule: It is a third protective covering that is made up of polysaccharides. It plays many roles but the important ones are to keep the bacterium from drying out and to protect it from engulfing by larger microorganisms.

Pilus: These are specifically small hairlike projections that emerges from the outside of the cell surface. It helps bacteria to attach to the host organism.

Flagella: (singular, flagellum) a hairlike structure that provides a means of location for bacteria. These are mainly found at either or ends of all over its surface.

Learn more about bacterial cells:

brainly.com/question/2145627

#SPJ4

the most abundant protein in the human body is (fill in the blank) ; it provides (fill in the blank). quizlet

Answers

Collagen is the most abundant protein in the human body.

Collagen is an essential component of all of our body's connective tissues. Our bones, skin, hair, joints, and other tissues all contain collagen. The skin may move, stretch, and recoil into shape with the help of collagen. The body contains collagen, which holds the cells together.

Without collagen, the body would disintegrate into nothing. A crucial structural protein of the numerous connective tissues of animals is collagen. Mammals produce a lot of protein, which accounts for 25 to 35 percent of the protein in the entire body.

Most collagen is found as elongated fibrils in fibrous tissues such tendons, ligaments, and skin.

Learn more about collagen here:
https://brainly.com/question/14596057
#SPJ4

lewis has three plants. he wants to know if giving a plant water, liquid fertilizer, or soap changes how it grows. which experiment should he do?

Answers

lewis has three plants. he wants to know if giving a plant water, liquid fertilizer or soap changes the way it grows. the experiment he must do is variable, being able to have plants with and without water, fertilizer and soap.

What is the dependent variable in this experiment what kind of soil is best for plant growth?

The dependent variable is plant growth. The variable that affects the dependent variable is called the independent variable. In the plant experiment, the independent variable can be fertilizer – some plants will receive fertilizer, others will not.

With this information, we can conclude that the experiment he must do is variable, being able to have plants with and without water, fertilizer and soap.

Learn more about  fertilizer affect plant in brainly.com/question/14290896

#SPJ1

the measurement of 17-ketosteroids (17-kss) in urine is performed to assess primarily which organ(s)?

Answers

The measurement of 17-ketosteroids (17-kss) in urine is performed to assess primarily the Adrenal Gland.

Adrenal Gland- The suprarenal glands, commonly known as the small, triangular-shaped adrenal glands, are situated on top of both kidneys. Hormones generated by our adrenal glands are responsible for regulating several vital bodily functions, including our immune system, blood pressure, stress response, metabolism, and other vital functions.

Hormones- Hormonal substances serve as messenger molecules in the body. They are produced in one part of the body and then circulate to other parts, where they assist in controlling the activity of cells and organs. For instance, the hormone insulin is produced by pancreatic beta cells.

To know more about Adrenal Gland, click on the below link,

https://brainly.com/question/733114

#SPJ4

Conditions in the body's immediate environment

Question 2 options:

Homeostasis


Climate


Electromagnetic Field


Pathogen

Answers

Answer:

Climate and Pathogen

Explanation:

Climate and pathogen are conditions in the body's immediate environment

In the whole-mantle convection model, what feature balances the deeply descending lithosphere by transporting hot material toward the surface?.

Answers

In the whole-mantle convection model, Mantle Plumes balances the deeply descending lithosphere by transporting hot material toward the surface

entire-mantle convection model states that cold, oceanic lithosphere descends into the mantle. warm mantle plumes delivery heat closer to the surface which offers downward arm of convective waftMantle Plumes is hot spots form with the aid of warm, strong fabric growing from narrow jetsconvection occurs when the extra energetic debris flow from the warmer region to the cooler region and take their warmness power with them alternatively a present day due to the rising of heated fluid and sinking of cooled fluid is called Convection modern

To know more about Whole-mantle convection model   visit : https://brainly.com/question/28444350

#SPJ4

When sampling repeatedly from a population, the pattern describing the values a statistic can take and how often it takes those values is the.

Answers

The correct answer is option 3) Sampling distribution of the statistic.

The Sampling distribution of the statistics describes the pattern that emerges while repeatedly sampling from a population and describing the possible values and frequency at which those values can be obtained.

Sampling distributions are vital for inferential statistics because they allow comprehending a single sample statistic in the context of other potential values. It outlines a variety of potential possibilities for a statistic, such as the mean or mode of a variable in a population. These distributions explain how a sample statistic fluctuates from one sample to the next.

Read more about Sampling distribution:

https://brainly.com/question/25343129

When sampling repeatedly from a population, the pattern describing the values a statistic can take and how often it takes those values is the

the bias of the statisticsampling variability of the statisticsampling distribution of the statisticstandard error of the statistic

Other Questions
At lunch, Noah buys two tacos for $2.35 each, chips and salsa for $1.85, and lemonade for $1.60. To pay for his meal, he uses $5.00 from a gift card he has, and then he pays for the rest with a $20.00 bill. Which equations show how much change Noah receives? Explain you answer I will mark you as the brainlyest Find the slope-intercept form of the line that is perpendicular to 2x+6y=1 and passes through the point (2,4) Please answer the two question in the photo [ Brainliest + points ] Whether or not a person detects a stimulus depends only upon that persons absolute threshold. True or false?. Select all of the equations that represent linear relationships.5+2y=13y=1x+7y-5=2(x-1)=x+7x=-4 When looking for a mathematical relationship between two variables use a as a result of the decline in available flu vaccines, the equilibrium price should , and the equilibrium quantity should What is the answer to this problem? Read the quotation from writer and activist James Baldwin (19241987).I love America more than any other country in this world, and, exactly for this reason, I insist on the right to criticize her perpetually.James Baldwin in Notes of a Native Son (1955)How does Baldwins declaration relate to the Constitutions preamble?The ideals stated in the preamble were not meant to be applied to real life.People who love their country should not criticize their government.It is important to question anything that does not meet the preambles ideals.The US has always stayed true to the ideals set forth in the preamble. how many significant digits are there in the number 2.25x10 using significant digits What is the decimal form of the given fraction 48/100 I need help asap!! (Geometry) Why is the plasma membrane considered as a barrier? Use the excerpt below to answer the question.Treaties made in the Pacific Northwest stipulated that the U.S. government would provide education to Native Americans living on reservations. Though it took several years, day schools and boarding schools were eventually established on reservations. In addition, boarding schools . . . were established off reservations. Students were required to live at boarding schools most of the year, thereby removing them from the influence of their families and traditional cultures.Library of CongressWhat was the purpose of the treaties described in the excerpt? How did reformers change the 19th century America? Which of the following government agencies' websites would be referenced to determine the infant mortality rate in the United States from1998-2004? How did Mrs.Dorling react when the narrator said, I am Mrs.ss daughter.? What is the process that wears away the surface of the earth? a disease agent can affect more than one organ of the body, and more than one disease agent can affect the same organ of the body. which term best describes this aspect of disease etiology? graph y=16-8x. .............