development of neuron-astrocyte co-culture system for mechanistic and pharmacological studies in neurodegeneration

Answers

Answer 1

Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease are characterized by the progressive atrophy and loss of neuronal function.

Lack of knowledge of the essential molecular pathways that cause neurodegeneration is one of the major barriers to the development of neuroprotective medicines for Parkinson's disease and other neurodegenerative illnesses. A deeper understanding of the diseases' molecular processes is urgently required. The lack of suitable in vitro models is a significant barrier to the creation of innovative neuroprotective therapies and the identification of early illness biomarkers. Furthermore, the majority of the ones that are available do not have active neuron-glia interactions. However, it is generally known that astrocytes are essential to both a healthy brain and to pathology, therefore their absence affects the applicability of these models.

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ringworm is caused by: group of answer choices worms infected with fungi invading the skin. dermatophytes that have invaded deep into the living tissue. a hypersensitivity caused by superficial contact with dermatophytes. toxins produced by dermatophytes. dermatophytes growing in the outer dead tissue layers of the skin (epidermis).

Answers

Ringworm is caused by C) dermatophytes growing in the outer dead tissue layers of the skin epidermis.

Ringworm is spread through pores and skin-to-pores and skin touch or via touching an infected animal or object. Ringworm is usually scaly and can be crimson and itchy. Ringworm of the scalp is common in children, where they could purpose bald patches.

Ringworm is a common fungal pore and skin infection otherwise called tinea. Ringworm maximum normally affects the skin on the frame tinea corporis, the scalp tinea capitis, the feet tinea pedis, athlete's foot, or the groin.

Ringworm after touching an animal that has ringworm. Many special sorts of animals can unfold ringworm to people, which include puppies and cats, especially kittens and puppies.

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Disclaimer:- your question is incomplete, please see below for the complete question.

A) worms infected with fungi invading the skin.

B) dermatophytes that have invaded deep into the living tissue.

C) dermatophytes growing in the outer dead tissue layers of the skin (epidermis).

D) a hypersensitivity caused by superficial contact with dermatophytes.

E) toxins produced by dermatophytes.

give a definition for the term "homology". what are two examples of homologous characteristics that today’s whales share with other mammals? why would the sleek shape of whales and their fins be analogous, and not homologous, to those of fish?

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The link between DNA or structures descended from the most recent common ancestor is known as homology.

For Example, Two prominent examples of homologous structures in evolutionary biology are the arms of primates and bats. Even though these two structures don't function or look like their most recent common ancestor, they are connected genetically. This means that a species' homologous traits may be accounted for by the fact that they have a common ancestor.

Flippers of Whale resembles with the Bat wing and the forelimb of human.

The whale fins help in swimming, bat wings help in flying, and the human forelimb helps in other normal works

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Which group of organisms contains no representative species that are known to fix nitrogen?.

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 Eubacteria group of organisms contains no representative species that are known to fix nitrogen.

Are microorganisms that fix nitrogen present  all plants?

It is known that some members of all major plant groups, as well as some fungi, can form symbiotic relationships with nitrogen-fixing bacteria. Although nitrogen-fixing bacteria have been found in animals, such as termite stomachs, there is still debate over the importance of these organisms to their hosts.

Eukaryotes are organism whose cells contain a nucleus and other membrane bound organelles. There is a wide range of eukaryotic organism, including all animals , plants , fungi , and Protists as well as most algae.

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No exceptions to the central dogma exist. Rna is always transcribed from dna, and rna is translated to produce proteins. True or false?.

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The statement 'no exceptions to the central dogma exist. RNA is always transcribed from DNA, and RNA is translated to produce proteins' is false.

Central dogma can be described as a process in which information from the DNA is converted into mRNA which in turn makes proteins. The process of making mRNA from DNA is referred to as transcription. The process of translating the mRNA into an amino acid sequence for the formation of proteins is referred to as translation.

When the retroviruses were discovered, an exception in the central dogma was observed. Retroviruses could change information from RNA to DNA through reverse transcriptase. Hence, the idea that DNA always changes into RNA is not correct as, in some cases like the retrovirus, RNA can convert into DNA.

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67. huang hh, liang y. integrating molecular interactions and gene expression to identify biomarkers and network modules of chronic obstructive pulmonary disease. technol health care 2022; 30: 135-142.

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Chronic obstructive pulmonary disease (COPD) is the world's top cause of death for the greatest number of individuals, known for its chronic obstructive diseases, chronic bronchitis, and emphysema.

How genes impact on COPD?The precise causal process of COPD is still unknown, despite several attempts to discover biomarkers and pathways. In order to better understand the biological mechanism and network module underlying COPD, this study integrates information on biological interactions with information on gene expression. 49 genes were chosen using a sparse network-based technique from the peripheral blood mononuclear cell expression data of 136 participants, comprising 42 ex-smokers and 94 COPD patients. The findings indicate that these 49 genes may have an impact on COPD-related biological functions and molecular processes.

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Many soil-dwelling bacteria produce molecules that can be naturally synthesized and kill other species of bacteria. What are these bacteria-killing molecules called?.

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These molecules that kill bacteria are known as anti-biotics.

Antibiotic literally translates to "against bacteria". It is a specific class of antimicrobial agent that works to kill bacteria. The use of antibiotic drugs is common in the treatment and prevention of bacterial infections since they are the most effective type of antibacterial agent. Bacterial growth may be prevented or killed by them.They either destroy the germs or make it difficult for them to proliferate and flourish.There are several ways to take antibiotics:Orally (by mouth): These could be tablets, capsules, or liquids.Topically: You might apply this to your skin as a cream, spray, or ointment. Additionally, it can be ear drops, eye drops, or eye ointment. Intravenously: an injection.

So, the answer is antibiotics.

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Does the formation of sperm is more in low temperature???​

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Answer:

Sperm production is a process that's sensitive to heat. Ideally, sperm production occurs around 93.2ºF, which is about 5ºF below normal body temperature. This is why the testes hang below the body to keep the temperature a bit lower.

Explanation:

Do cells use carbohydrates as a source of amnio acids

Answers

Answer:

Yes sssdddddsdsssss

Explanation:

tutututytytututuytutyrut

Under a microscope you view a cell with an extensive smooth endoplasmic reticulum present. What could this indicate?.

Answers

The cell has a high energy demand.The clean endoplasmic reticulum capabilities in lots of metabolic processes. It synthesizes lipids, phospholipids as in plasma membranes, and steroids. Cells that secrete those merchandise, which includes cells of the testes, ovaries, and pores and skin oil glands, have an extra of clean endoplasmic reticulum.

Large quantities of clean ER are located in liver cells in which one in every of its important capabilities is to detoxify merchandise of herbal metabolism and to endeavour to detoxify overloads of ethanol derived from extra alcoholic ingesting and additionally barbiturates from drug overdose.

Smooth ER includes an extended community of a folded, tube-like structure. You can think about it like a pipeline with a variety of twists and turns. The indoors of the clean ER is known as the lumen, that is enclosed via way of means of a phospholipid membrane, much like the membrane that encloses the complete cell.

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The biggest difference between channel proteins and carrier proteins, is that...
A. channel proteins can also allow much larger particles to cross the membrane than carrier proteins can.
B. carrier proteins are usually very narrow and takes on a specific shapes, and channel proteins change shape.
C. channel proteins require movement, unlike carrier proteins.
D. unlike channel proteins, carrier proteins do not create a continuous open passage all the way through the membrane.

Answers

The biggest difference between channel proteins and carrier proteins, is that unlike channel proteins, carrier proteins do not create a continuous open passage all the way through the membrane. That is option D.

What are protein transporters?

Protein transporters are those molecules found on or within the cell membrane that helps in the transportation of ions in and out of a cell.

Examples of protein transporters include the following:

Channel proteins: These are the protein transporters that penetrates through the cell membrane thereby allowing the flow of ions in and out of the cell through the process of diffusion.

Carrier proteins: These are protein transporters that are located on the surface of a cell membrane without penetrating through it.

Therefore, the biggest difference between channel proteins and carrier proteins, is that unlike channel proteins, carrier proteins do not create a continuous open passage all the way through the membrane.

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Each myosin protein has a globular head that extends outward from the myosin filament. True or false?.

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True: Each myosin protein has a globular head that extends outwards from the myosin filament.

Actin and myosin are the two types of proteins found in every kind of muscle cell or tissue. The thick filament is called myosin and the thin filament is called actin. The myosin and actin filament slide over one another to cause movements. The globular head of the myosin proteins in the myosin filament is extended outwards to facilitate the binding of actins.

The myosin filament in muscles consists of two heavy chains and two pairs of light chains. Each heavy chain consists of two parts: globular head region and ∝-helical tail. The globular heads of the myosin bind actin and form a cross-bridge between the thick and thin filaments. Myosin heads also bind and hydrolyze ATP to derive the energy required for sliding.

The globular head of the myosin protein is extended outward from the individual filament to facilitate actin binding.

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invertebrates and fish that eat dead organic matter will be most abundant in the of freshwater lakes.

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Invertebrates and fish that eat dead organic matter will be most abundant in the benthic zone of freshwater lakes.

In a marine water body, the most lowest zone in terms of ecology is called benthic zone. It name comes from the Greek letter βένθος which means 'depths'.

In this zone, sediments lay down at floor of the sea and provide essential nutrients and minerals to the organisms living in this zone.

Benthic zone, also referred to as ecological zone, possesses peculiar characteristics such as high pressure and low temperature.

The sediments of this zone recycle the nutrients and help in the survival of aquatic organisms.

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The main purpose of a forester is to identify land for timber harvesting.

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A forester is a professional whose work is to assess woodlands, identify or estimate timber and non-timber values, recommend/design/supervise possible activities, including harvesting, to accomplish a range of goals, and help landowners plan for the future.

Which of the following is not one of the eight characteristics of life?
A) Homeostasis
B) Growth
C) Movement
D) using energy and resources

Answers

Answer:

Suppose D since even non living things could use energy

38. Based on their characteristics, soils are classified into orders. Give the order for each of the different types of soils:
new soils that have recently formed, often by flooding
older, heavily weathered soils
prairie soils
woodland soils

Answers

Soil Taxonomy classifies soils at the most fundamental level into one of 12 groups known as "orders."

New soils that have recently formed, often by flooding - Entisols Older, heavily weathered soils - Ultisols Prairie soils - Mollisols Woodland soils - Alfisols

These orders of soil in Soil Taxonomy each represent a collection of soils with unique traits and ecological importance. The soil classification/Soil Taxonomy system has multiple degrees of information, from the most basic to the most intricate, just as the classification systems for plants and animals.

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Why don't birds get electrocuted when they land on an electric wire? Pls answer, will give 20 points.

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A bird just sitting on a wire doesn't touch the ground, or anything in contact with the ground, so electricity stays in the power line. However, if a bird were to touch a power line as well as equipment or other metal that is grounded, it could potentially give electricity a path to the ground and the bird could be shocked.


When a bird is perched on a single wire, its two feet are at the same electrical potential, so the electrons in the wires have no motivation to travel through the bird’s body. No moving electrons means no electric current. The bird is safe, however if that bird stretches out a wing or a leg and touches a second wire, especially one with a different electrical potential, it will open a path for the electrons — right through the bird’s body.

Power lines carry alternating currents or AC where the electric current regularly changes direction. Over time the voltage alternates between positive and negative indicating the direction of voltage flow. Voltage is the difference in charge between two points, whilst current, measured in amperes, or amps, is the rate at which the charge is flowing. The number of cycles per second is measured in Hertz (Hz) and average power lines have a frequency of 50 Hz. Because the voltage in the wire is constantly changing, the voltage of a bird sitting on a wire is also changing. In other words, the bird is constantly being charged and discharged through its feet.


The other thing we need to think about is the capacitance of the bird. This is the ability of the bird to collect and store electric charge. Because birds are very small and shaped a bit like spheres, they can’t store much electric charge. In fact, when a bird sits on a 50 Hz power line it can only carry a current in the order of microamps (μA), or 0.00000001 amps.


So although the bird does have a current running through its body, it is too small to electrocute it or even give it an electric shock. For comparison, a current of about 10 milliamps (0.01 amp) is enough to produce a painful shock in humans, and electrocution is possible from about 50 milliamps. We don’t know whether birds perched on power lines can feel the current going through their bodies. Perhaps they enjoy the buzzing sensation that they may be feeling and perhaps this explains why you don’t often see big birds, with a larger capacity, sitting on power lines.


A bird is also made of cells and tissues. These cells and tissues do not provide the electricity in the wire with an easier route to travel than the one it is already on. Because a bird's body is not a good conductor of electricity, the electricity essentially ignores the bird on the wire and continues to travel along the copper wiring to its destination. In fact, humans would also be able to not be shocked by a power line if we hung suspended from the power line with both of our hands on the line and no other grounding objects around us.

Answer:

bird's don't get electrocuted when they land on electric wire because their legs don't have blood

charlotte looks at a plant through a microscope and notices that the plant cells are packed with green chlorophyll. there is also a thin waxy layer at the top of the segment. what part of the plant is she most likely viewing?

Answers

The part of the plant where cells are packed with green chlorophyll and there is also a thin waxy layer at the top of the segment can be the leaves.

Chlorophyll is the green colored pigment found in the plants. It is present inside the chlorophyll and is involved in the process of photosynthesis. The function of the chlorophyll is absorb the energy from the sunlight, which participates in the light reaction.

Leaves are the thin flattened structures of the plant that arise from the stems. They are mostly green in color and whole cells are rich in chlorophyll. The function of the leaves if to make food for the entire plant by photosynthesis.

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Which of the following are examples of processes in your body that we must keep balanced?

A. Blood sugar levels, heart rate, wrinkles on our skin, and brushing our teeth

B. Body temperature, finger nail growth and food intake

C. Body temperature, blood sugar levels, and blood pressure

D. None of the above

Answers

Answer:

option = c the process in body that w must keep balanced are body temperature, blood sugar levels and blood pressure

Body temperature, blood sugar levels, and blood pressure are examples of processes in your body that we must keep balanced. Therefore, option (C) is correct.

Body temperature, blood sugar, and blood pressure must be adjusted for health. Homeostatic mechanisms control these physiological processes to preserve internal stability and optimise cellular and organ function.

To facilitate metabolism and enzyme activity, body temperature is tightly controlled. To keep cells energised and avoid consequences from excessive or low blood sugar, glucose levels must be managed. Controlling blood pressure ensures adequate blood circulation and protects blood vessels and organs.

Option A includes wrinkling and tooth brushing. Option B contains unregulated processes like fingernail growth and food intake. Option D claims that none of the following are balanced processes, yet option C lists balanced bodily processes.

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novel cell types and developmental lineages revealed by single-cell rna-seq analysis of the mouse crista ampullaris

Answers

On ampullae microdissected from E16, E18, P3, and P7 mice, single-cell RNA-seq was carried out.

Briefing:

The crista's hair cells, support cells, and glia were discovered by cluster analysis, along with the ampulla's dark cells and other nonsensory epithelial cells, mesenchymal cells, vascular cells, macrophages, and melanocytes.

The new cell types identified by single-cell RNA-seq may be crucial for comprehending crista function, and the markers found in this study may make it possible to examine how these cells change during development and disease.

Where are the vascular in the body?

The network of blood vessels known as the vasculature connects the heart to all other organs and body tissues. Organs and tissues receive oxygen-rich blood and nutrients from the heart through arteries and arterioles, while deoxygenated blood is returned to the heart by veins and venules.

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the transcription factor zeb2 regulates development of conventional and plasmacytoid dcs by repressing id2.

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Answer: Zeb2 controls commitment to both the cDC2 and pDC lineages by inhibiting Id2.

Explanation: Pre-pDCs give rise to plasmacytoid dendritic cells, whereas pre-cDCs, which are lineage-committed, give rise to the two lineages of conventional dendritic cells (cDC1 and cDC2). The formation of pDCs and cDC1s has been linked to a number of transcription factors , but it is uncertain whether TFs are necessary for pre-cDCs to commit to the cDC2 lineage at an early stage. From the pre-pDC and pre-cDC stage on, Zeb2 was expressed, and it was significantly expressed in mature pDCs and cDC2s. Id2 was discovered to be a specific target of Zeb2 by chromatin immunoprecipitation research. We thus deduce that Zeb2 controls commitment to both the cDC2 and pDC lineages by inhibiting Id2.

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what term describes the measure of how quickly a carbohydrate will raise an individual’s glucose levels when consumed on its own, irrespective of the amount eaten?

Answers

Glycaemic index is used to measure the amount of carbohydrates that will raise an individual’s glucose levels.

Glucose is a sweet sugar and belongs to the class of carbohydrates.

It is obtained from food that we consume and in response our body utilizes it for energy purposes.

Glycaemic index of food refers to the time period during which carbohydrates are disintegrated and absorbed in the blood.

If GI is higher then it will enter the blood more quickly as compared to lower GI levels.

Higher GI levels means higher glucose levels in the blood and vice versa.

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formulate three questions a scientist might wonder about after reviewing this data, demonstrating the merit these findings have in the scientific community about florida panther

Answers

The questions that a scientist may formulate are regarding the sample size, the difference between the hypothesis and observation, cause of the result can be asked by the scientist regarding their research.

What is scientific data?

Scientific data is a relational category that is applied to the results of the study. These are noticed at certain times during the experiment and are used to support the knowledge and interest claims made by the researchers taking part in the investigation.

With regard to themselves, they lack integrity. Additionally, they do not accurately depict certain phenomena. They are fairly malleable items that may be scaled up or down, and their value as evidence defines them.

Therefore, questions regarding the sample size, the difference between the hypothesis and observation, cause of the result can be asked by the scientist regarding their research.

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macrophage are immune system cells that patrol the blood and body tissues. when a macrophage finds a foreign invader, the macrophage ingests (takes in) the foreign invader and then chemically digests (breaks down) that foreign invader. to perform this frequent chemical digestion, macrophage have more than the average body cell.

Answers

macrophage are immune system cells that patrol the blood and body tissues. when a macrophage finds a foreign invader, the macrophage ingests (takes in) the foreign invader and then chemically digests (breaks down) that foreign invader. to perform this frequent chemical digestion, macrophage have more than the average body cell is

Macrophages are immune system cells that are vital to the development of non-specific defense mechanisms that provide the first line of defense against pathogens. These large immune cells are present in nearly all tissues and actively remove dead and damaged cells, bacteria, cancerous cells, and cellular debris from the body.

What is Macrophages?

Macrophages are specialized cells that hunt for, engulf, and kill bacteria and other dangerous organisms. They can also activate other cells by releasing substances known as cytokines, which present antigens to T cells and start an inflammatory response.

Blood monocytes that leave the bloodstream to differentiate in various organs give rise to macrophages. Each macrophage population exhibits significant variety, which most likely reflects the level of specialization necessary for each tissue's environment.

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How to cure ringworm?
What component of plant cells does the tobacco mosaic virus infect?

Answers

Ringworm can be cured through non-prescription remedies such as creams, powders, lotions, and other skin-friendly fixtures for a maximum of four weeks, which is a month. The tobacco mosaic virus infects all parts of the plant (including the cell structures) through a protein transferral called a plasmodesmata. With the transportation available through these proteins, the cell gets infected in all its parts.

darwin was well aware of what effect his theory of evolution would have on the public and on the church of england.

Answers

Darwin was well aware of what effect his theory of evolution would have on the public and on the church of England.

The statement is true.

Darwin's groundbreaking theory was that new species do not originate from God's eternally unchangeable creation but rather develop organically via a process of evolution.

Darwin held off on releasing his findings for several decades while he gathered more evidence because he was fully aware of the effect his theory of evolution would have on the general public and the Church of England. He suggested that natural populations can also change after citing selective breeding of tamed animals as proof that groupings of creatures can undergo change.

The public and religious establishment in Britain was astonished when Darwin's work was first made public in 1859.

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natural selection is a fundamental mechanism driving the evolution of species. to research this conclusion, a group of scientists wants to test the effects of increased ocean acidity on a population of coral. what result from this experiment would confirm that natural selection is a process that can drive evolution? (3 points)

Answers

Certain coral would end up dying, and some coral would grow and change to withstand and survive the ocean acidity.

which term best describes the organization of the nervous system? please choose the correct answer from the following choices, and then select the submit answer button. answer choices hierarchical random linear disconnected

Answers

Hierarchical is the word that best explains how the nervous system is organized.

What exactly is a nervous system?The control center of your body is your neurological system. It is controlled by your brain and governs your actions, thoughts, and automatic reactions to your environment. Additionally, it regulates other bodily functions and systems, including digestion, breathing, and sexual development (puberty).Why is the nervous system so crucial?The nervous system facilitates communication between all body parts. In addition, it responds to alterations both inside and outside the body. The nervous system transmits and receives information using both chemical and electrical methods.There are two primary sections of the nervous system: The brain and spinal cord make up the central nervous system.

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9. Explain the benefits and
limitations of each
type of scientific investigation.

Answers

The benefits and limitations of each type of scientific investigation are listed below:-

Benefits:-

A descriptive investigation is concerned more about observations related to natural systems which are recorded through a systematic method of data collection. A comparative investigation do not essentially require control variables since it is not carried in a laboratory.An experimental investigation tends to study the 'cause' and 'effect' relationship between two variables through the use of control variables in order to maintain a constant environment.

Limitations:-

A descriptive investigation fails to compare the data collected and establish a causal relationship between the variables.A comparative investigation fails to control the variables that are present naturally and might affect the research.An experimental investigation may sometimes fail to explain real-life incidents since they are based on a hypothesis.

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How can you justify that Golgi exhibits the phenomenon of membrane flow?

Answers

The phenomenon of membrane flow is a good thing to do with the lake and the house is a bit too high to see

Our body needs Oxygen and Glucose to ensure which process can take place in our
body?

A. Homeostasis
B. Photosynthesis
C. Thermoregulation
D. Cellular Respiration

Answers

Answer: Number D

Explanation: During aerobic cellular respiration, glucose reacts with oxygen, forming ATP that can be used by the cell. Carbon dioxide and water are created as byproducts.

Answer:

The answer will be

D). Cellular Respiration

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